TCT Meeting 2022 GVHD News
Researchers examined outcomes in peripheral blood haplo-HCT and their relation to pre-operation measurable residual disease. The phase II study had enrolled 63 patients at the time of the interim analysis. Venkata S. Thammineni, MD, and colleagues conducted a meta-analysis to assess the effect of graft CD on allo-PBSCT outcomes. Researchers examined the relationship between extracellular vesicle antigen expression and their microRNA cargo. The poster advanced a total of 27 "candidate protein biomarkers which may predict occurrence of aGVHD." A studyobserved “encouragingly” positive results in reducing severe acute graft-versus-host disease (aGVHD). The data were presented by the study’s lead author, Meredith Jo McAdams, MD, at the TCT 2022 Tandem Meetings. Researchers presented updated data from the phase Ib/II EQUATE trial. Researchers sought to characterize outcomes of pediatric patients who developed SR-aGVHD after allogeneic HSCT. A poster investigated the clinical outcomes in German patients who developed acute graft-versus-host disease. The study sought to improve graft-versus-host disease prophylaxis in haploidentical hematopoietic stem cell transplant. Researchers theorized that inhibiting JAK1 with itacitinib could prevent aGVHD and CRS in certain patients. Orca-T appeared to yield a reduction in chronic graft-versus-host disease. Researchers evaluated the presence of innate lymphoid cells in unmanipulated, lymphocyte-replete HCT grafts. Researchers evaluated the rate of failure-free survival after belumosudil treatment for chronic graft-versus-host disease. The investigators measured plasma vitamin E levels with high-performance liquid chromatography.